【摘要】 目的:探讨ＭｇＳＯ４对大鼠脑缺血再灌流损伤的保护作用。方法:线栓法将ＳＤ大鼠制成脑缺血再灌流模型,分组测定脑组织Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ活性、ＭＤＡ、ＮＯ含量。结果:治疗１组(３００ｍｇ·ｋｇ－１)和治疗２组(６００ｍｇ·ｋｇ－１)与对照组比较,Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ活性增加,ＭＤＡ、ＮＯ含量降低,且治疗２组比治疗１组作用更明显。结论:ＭｇＳＯ４对脑缺血再灌流损伤有保护作用,６００ｍｇ·ｋｇ－１较３００ｍｇ·ｋｇ－１更显著。更多还原

【Abstract】 Aim: To evaluate therapeutic effects of magnesium sulfate (MgSC4) after cerebral ischemic reperfusion. Methods: Using the Sprague-Dwaley(SD) rat model of cerebral ischemia and reperfusion (middle cerebral artery occlusion,MCAO), we observed the Na+-K+-ATPase activity changes, malonicaldehyde(MDA) and nitricoxide (NO) levels. Results:Compared with the control groups,cerebral Na+-K+-ATPase activity in the treatment group increased, MDA and NO decreased significantly, the changes were more significant in treatment No. 2 group than in treatment No. 1 group. Conclusion:MgS04 has an obvious protective effect when administered after cerebral ischemia and reperfusion, furthermore, the larger dose of MgS04 administration has much better protective effects than the smaller dose.更多还原