【摘要】 目的 :探讨 IL- 4、IL- 5等 8种细胞因子在鼻息肉发病中的作用和对鼻息肉治疗的意义。方法 :采用酶联免疫吸附实验 (EL ISA)法检测 2 5例鼻息肉患者鼻息肉组织中 Th1 细胞因子 IFN- γ、IL- 2、IL- 12和 Th2 细胞因子 IL- 4、IL- 5、IL- 8、IL- 10、IL- 13的表达 ,并比较经皮质激素治疗前后鼻息肉中细胞因子表达的差异。结果 :2 5例中 ,IL- 4、IL- 5、IL- 8、IL- 10、IL- 13等 Th2 细胞因子的表达较正常组织增高 ,其中以 IL- 4、IL- 5最为显著 ,分别达3.9倍和 8.8倍 ;应用皮质激素后细胞因子的表达水平显著降低 ,而 IFN- γ、IL- 2、IL- 12等 Th1 细胞因子浓度较正常组织中降低 ,应用激素后其表达无明显改变。结论 :Th2 细胞因子 IL- 4、IL- 5、IL- 8、IL- 10、IL- 13等的升高 ,在鼻息肉的发病过程中可能具有重要的意义 ,通过改变 Th2 细胞因子的表达趋势 ,可能对鼻息肉的治疗具有一定的意义。更多还原

【Abstract】 Objective:To evaluate the possible role of cytokines in pathophysiology and treatment of nasal polyps.Method:The expressions of Th 1 typed cytokines IFN γ、IL 2 、IL 12 and Th 2 typed cytokines IL 4、IL 5、IL 8、IL 10、IL 13 were investigated with enzyme linked immune sorbent assay(ELISA) in 25 patients with nasal polyps.Result:There was a significant upregulation of Th 2 typed cytokines IL 4、IL 5、IL 8、IL 10、IL 13 in nasal polyps compared with normal nasal mucosa, especially IL 4 and IL 5 ( 3.9 times and 8.8 times higher than normal mucous respectively) while the expression of Th 1 typed cytokines IFN γ、IL 2、IL 12 drcreased after treated with local glucocorticoid. The levels of Th 2 typed cytokines decreased significantly and Th 1 typed cytokines had no obvious change.Conclusion:The upregulation of Th 2 typed cytokines such as IL 4、IL 5、IL 8、IL 10、IL 12 may play an important role in the pathophysiology of nasal polyps and Th 2 typed cytokines can be viewed as a target of treatment to nasal polyps.更多还原