【摘要】 为了研究L -D ,即左旋荷包牡丹碱抗心律失常的作用 .用动物心律失常的实验模型研究L -D对BaCl2 ,CaCl2 ,肾上腺素、氯仿、乌头碱、哇巴因诱发的心律失常的影响 ,结果 :左旋荷包牡丹碱静脉注射10mg/kg能使BaCl2 所致的大鼠心律失常迅速转为窦性节律 ,可明显提高乌头碱引起大鼠室颤和死亡的用量 ;降低CaCl2 所致大鼠和氯仿所致的小鼠的室颤发生率和死亡率 ;对肾上腺素、哇巴因诱发的心律失常有明显的对抗效应 ;对电刺激下丘脑引起的心律失常有显著的保护效应 .结果表明 :左旋荷包牡丹碱具有抗心律失常的作用 .更多还原

【Abstract】 To observe Antiarrhythmic effects of L-dicentrine.Methods using experimented model of arrhythmials.Results: L-dicentrine iv l0 mg/kg could convert BacRinduccd arrhythmia into sinus rhythm in rats,and could significantly increase the tolerant dose of aconine to produce Ventricular fibrillation (VF) and Cardiac [rrest (ca) in rats. The drug could also decrease the incidence of VF and CP by cardiac rats and by chloroform in mice. L-dicelltrine had protective effects on ouabain induced Arrhythmias in guined pigs and on adrenalice induced arrhythmias in rabbits. The drug might also inhibit the arrhymias induced by stimulation ofhypothaplus. Conclusion: L-dicenirine have significant antiarrhythmic properties.更多还原