【摘要】 建立家兔内生致热原性发热模型 ,观察解热醒神注射液对发热动物的体温及下丘脑cAMP、IL 1β 含量的影响。结果显示 :解热醒神注射液组的体温变化曲线、最大体温上升高度 (ΔT)、体温反应指数 (TRI3)与生理盐水组无明显差别 (P >0 0 5 ) ,表明解热醒神注射液对正常体温影响不大。而解热醒神注射液 +内生致热原组的ΔT、TRI3及下丘脑cAMP、IL 1β 含量明显低于内生致热原组 (P <0 0 1) ,4组家兔的体温变化与cAMP及IL 1β 含量变化呈正相关。说明解热醒神注射液不但抑制内生致热原引起的发热反应而且抑制内生致热原引起的下丘脑cAMP及IL 1β 含量的增多。更多还原

【Abstract】 The effects of Jierexingshen Injection (JI) on the body temperature and the levels of cAMP and IL 1 β were observed in the hypothalamus of the rabbits with endogenous pyrogen (EP) induced fever. The results showed that there was no obvious difference between the body temperature curve and the levels of ΔT and TRI3 in the animals in the JI group and those in the animals in the normal saline group ( P >0.05), which implies that JI has no great influence on normal body temperature. The results also showed that the levels ofΔT and TRI3 and the levels of cAMP and IL 1 β in the hypothalamus of the animals in the JI plus EP group were significantly lower than those in the EP group ( P <0.01), with a positive correlation between the changes in the body temperature and the changes in the levels of cAMP and IL 1 β, which implies that JI not only can inhibit the increase of the body temperature induced by EP, but also can inhibit the increase of the levels of cAMP and IL 1 β in the hypothalamus caused by EP.更多还原