【摘要】 目的 :研究 2 -乙基 - 3-羟基 - 6-苯硫基 - 4 ( 1H) -吡啶酮 (HPP)对四氯化碳 (CCl4 )、硫代乙酰胺 (TAA)及D -氨基半乳糖 (D -GalN)引发的小鼠急性肝损伤的影响 .方法 :用CCl4 、TAA、D -GalN引发动物急性肝损伤 ,HPP通过口服给药 ,测定动物血清中谷丙转氨酶 (GPT)、谷草转氨酶 (GOT)、谷胱甘肽过氧化物酶 (GSH -Px)、超氧化物歧化酶 (SOD)的活性 ,用硫代巴比妥酸法测定肝组织中丙二醛 (MDA)含量 .结果 :HPP 1.6mg·kg- 1、6.4mg·kg- 1显著抑制动物血清中GPT、GOT活性的升高 ,显著抑制GSH -Px ,SOD活性的降低且能降低肝组织中脂质过氧化产物MDA含量的升高 ,同时HPP对CCl4 所致大鼠急性肝损伤也有一定的抑制作用 ,实验表明HPP对正常小鼠血清及肝脏GPT活力无明显影响 .结论 :HPP对动物急性肝损伤有明显的抑制作用更多还原

【Abstract】 Aim:To study the protective effect of 2-ethyl-3-hydroxy-6-phenylthio-4-(1H)-pyridinone (HPP) on acute liver injury induced by CCl 4、TAA and D-GlaN. Methods:The animals liver injury was induced by CCl 4、TAA and D-GlaN, HPP was administered via ig , the activities of serums GPT,GOT,GSH-Px and SOD were tested respectively. The levels of MDA in liver tissues were measured by thiobarbituric acid method. Results:HPP at the doses of 1.6, 6.4 mg·kg -1 remarkably inhibited the activities of serum GPT,GOT and decreased the MDA levels in liver tissues in mice or rats. Conclusion:HPP could remarkably inhibit experimentary liver injury in mice or rats. [更多还原