【摘要】 目的　探讨上皮性卵巢癌的危险因素。方法　采用 1∶ 2匹配的病例 -对照研究。于 1997～ 1998年 ,在江苏南通市和连云港市共选取经病理学检查确诊的原发性上皮性卵巢癌住院病人10 3例 ,对照 2 0 6例。结果　单因素条件 logistic回归分析表明 :高产次、月经初潮晚、哺乳时间长及体重指数 (BMI)高可能是保护因素 ;使用宫内节育器以及使用时间长、有妇科恶性肿瘤家族史及染发次数多可能为危险因素。在进行多因素模型拟合时 ,产次、染发、使用宫内节育器、哺乳及职业5个因素进入了方程。结论　结果从总体上支持 Fathalla的排卵假说 ;上皮性卵巢癌与卵巢恶性肿瘤 (未进行病理分型 )的危险因素基本一致更多还原

【Abstract】 Objective To illustrate risk factors for epithelial ovarian cancer. Methods An 1∶2 matched hospital based case control study was conducted between 1997 and 1998 in Nantong and Lianyungang city, Jiangsu. The study included 103 pathologically confirmed primary epithelial ovarian cancer cases and 206 controls. Results Single factor conditional logistic regression analysis showed that parity, late age of menarche, long breast feeding duration and high body mass index(BMI) were protective factors for the disease, while intrauterine device(IUD) use, IUD use duration, family history of gynecological malignant tumors and hair dyeing were risk factors for epithelial ovarian cancer. Parity, hair dyeing, IUD use, breast feeding and occupation entered multiple factor regression model. Conclusions The result tends to support Fathalla’s theory of incessant ovulation and no difference was found in risk factors between epithelial ovarian cancer and ovarian malignant tumor.更多还原