【摘要】 目的　了解尿毒症患者呼吸中枢 -呼吸肌 -肺的功能变化。方法　分别测定了 2 5例尿毒症患者及2 0例正常人的用力肺活量 (FVC)、最大通气量 (MBC)、1秒钟用力呼气容积 (FEV1 )、最大呼气流量 (PEF)、最大呼气中段流量 (MMEF)、2 5 %肺活量最大呼气流量 (·V2 5)、肺一氧化碳弥散量 (DL co)、最大吸气口腔压 (MIP)及口腔阻断压 (P0 .1 )等参数。结果　尿毒症患者反映肺通气功能指标 FVC、MBC、FEV1 、PEF、MMEF、·V2 5及肺弥散功能指标 DLco均明显低于正常人 ;吸气肌力指标 MIP也明显低于正常人 ;而呼吸中枢兴奋性指标 P0 .1 则显著高于正常人。结论　尿毒症患者在肺通气及弥散功能降低的基础上 ,存在着吸气肌力的下降及呼吸中枢兴奋性的增高更多还原

【Abstract】 Objective To investigate the changes of central respiratory drive and inspiratory muscles function in patients with uremia. Methods\ We performed the measurement of forced vital capacity (FVC), maximal voluntary ventilation(MBC), forced expiratory volume in one second (FEV 1), peak expiratory flow(PEF), maximal midexpiratory flow(MMEF), expiratory flow of 25 per cent of FVC(·V 25 ), lung carbon monoxide diffusing capacity (DLco), maximal inspiratory mouth pressure (MIP)and airway occlusion pressure (P 0.1 ) in 25 patients with uremia and 20 normal subjects. Results\ In patients with uremia, the FVC, MBC, FEV 1, PEF, MMEF and ·V 25 which reflect the lung ventilatory function and the DLco which reflects the lung diffusing function were significantly lower than those in normal subjects. The patients’ MIP which reflects inspiratory muscles strength was significantly lower and their P 0.1 which reflects the central respiratory drive was significantly higher, compared with the normal subjects’. Conclusion Our findings suggest that on the basis of the disorder of ventilation and diffusing function of the lungs,the inspiratory muscles function of the patients with uremia is significantly decreased and the central respiratory drive of the patients is increased. [更多还原