【摘要】 目的 :探讨腭裂与胚鼠的犁骨、Jacobson器官和鼻中隔旁软骨发育的关系。方法 :借助计算机图像处理系统 ,测定 30对处于相同或相近发育阶段的 18三体伴腭裂胚鼠和正常胚鼠颅上颌复合体冠状序列连续切片中犁骨最大横截面积和Jacobson器官、鼻中隔旁软骨在原发腭与继发腭交界平面的横截面积 ,并估算犁骨在矢状平面的长度。进一步对腭裂及非腭裂组进行量化比较。结果 :18三体伴腭裂小鼠的鼻中隔旁软骨及犁骨在冠状面和矢状面的发育均伴有严重的发育不足 ,而Jacobson器官在腭裂及非腭裂组无显著性差异。结论 :18三体伴腭裂小鼠鼻中隔前部附属器官硬组织发育不足不仅与腭裂密切相关 ,而且很可能与常染色体三体条件关系更密切更多还原

【Abstract】 Objective: The aim of this study was to investigate whether cleft palate is associated with the mal_development of the vomer, Jacobson′s organ and para_septal cartilage.Methods: Sixty craniomaxillary complexes, which came from 30 pairs of trisomy 18 with cleft palate (Ts+CP) and euploid mouse fetuses were precisely orientated in the coronal plane, and serially sectioned at 7μm thickness. With the aid of computer imaging analysis system the vomer in coronal and sagittal direction, Jacobson′s organ and para_septal cartilage in the boundary plane of the primary and secondary palate were measured and compared quantitatively.Results: The hard tissues (including the vomer and para_septal cartilage) of the anterior nasal septum in Ts+CP foetuses show serious developmental hypoplasia, however, the Jacobson′s organ had no significant different between the cleft and non_cleft samples.Conclusion: Developmental hypoplasia of these hard tissues may be more closely related with the autosomal trisomic condition more than the cleft palate.\;更多还原