【摘要】 目的 :探讨赠卵在体外受精—胚胎移植(IVF-ET)的临床疗效。方法 :通过23例赠卵者28个周期2种方案促超排卵 ,28例受者31个周期2种方案经甾体激素准备子宫内膜并接受胚胎移植 ,比较不同方案下促排卵及子宫内膜准备与临床妊娠率的关系。结果 :受者31个周期的临床妊娠率48.4 % ,以不同方案促排卵、子宫内膜准备其相应的临床妊娠率无显著性差异(P>0.05)。结论 :赠卵IVF -ET是一种妊娠率较高的助孕技术 ,适用于卵巢早衰 ,常规IVF -ET失败者更多还原

【Abstract】 Objective:To explore the clinical effect of oocyte donation in vitro fertilization-embryo transplant (IVF-ET). Method: The super ovulation was introduced in 28 oocyte donation cycles with gonadotropin-releasing hormone analogue 1(GnRH-a)/human menopausal gonadotropin (hMG)( n=13) and GnRH-a/FSH + hMG( n=13). Sex steroids were used to prepare the receptivity of the recipients’ endometrium in 31 cycles with estradiol(E) + progestrone(P)( n=13) and GnRH-a/E + P( n=18) respectively.The clinical pregnancy rate were compared between two methods of the super ovulation and two methods of endometrium preparation. Results: 15 cycles (48.4%) out of 31 cycles with embryo transplant were resulted in clinical pregnancy. The pregnancy rates were no significant differences statistically between two methods of the super ovulation and two methods of endometrium preparation. Conclusion: Ooocyte donation IVF-ET is an effective treatment option for the infertile couples with ovarian failure or repeated unsuccessful trial of assisted reproductive technology.更多还原