【摘要】 目的 :探讨IL 8、TNF α及sC5b 9在心肌梗死 (AMI)患者血清中的动态变化及其与心肌酶的相关性。方法 :用双抗体夹心酶联免疫吸附法对 38例AMI患者及 40名健康人进行血清IL 8、TNF α及sC5b 9测定。结果 :AMI患者血清IL 8、TNF α及sC5b 9含量明显升高 ,与健康人比较有显著性差异 (P <0 0 1) ;在AMI发病后第 7天 ,IL 8、TNF α及sC5b 9水平逐渐下降 ,到第 2 8天上述变化仍未达到对照组水平。其上升幅度与心肌酶值成正相关。结论 :AMI患者的病情及发展与心肌酶峰值有关 ,也与IL 8、TNF α及sC5B 9的血清动态变化有关。更多还原

【Abstract】 Objective: To study the changes of serum interleukin 8(IL 8)?tumor necrosis factor α(TNF α) and complement activation (sC5b 9) levels in acute myocardial and the relationship with myocardial enzyme.Methods: By use of enzyme linked immunosorbent assay (ELISA),changes of serum interleukin 8?tumor necrosis factor α and composition of complement activation (sC5b 9) levels were measured in 38 AMI and 40 healthy controls.Results: The serum interlenkin 8?tumor necrosis factor α and composition of complement activation (sC5b 9) levels were higher in AMI than those in healthy control ( P < 0.01 ).The levels of cytokines and complement began to recover form 7 days after the AMI but they did not reach the normal level until 28 days after AMI.And the levels in serum were correlated with the number of myocardial enzyme.Conclusion: The changes of case in AMI are connected with the highest number of myocardial enzyme and the levels of serum IL 8?TNF α?sC5b 9.更多还原