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抗病毒1号中药在Hela细胞中对呼吸道合胞病毒的抑制作用
The Anti-Respiratory Syncyntial Virus Effect of a Chinese Medicinal Herb-No. 1 in Hela Culture
【摘要】 为了解抗病毒1号单味中草药对呼吸道合胞病毒的抑制作用,本研究采用细胞培养技术,以病毒唑为阳性对照药,观察抗病毒1号对呼吸道合胞病毒的抑制作用。结果表明,抗病毒1号和病毒唑的半数中毒浓度(TC50)分别为13.9mg/ml、76.43ug/ml;其抗呼吸道合胞病毒的半数有效浓度(EC50)分别为0.827mg/ml、5.672ug/ml,TI分别为16.81、13.47;抗病毒1号对呼吸道合胞病毒的抑制作用存在着明显的量效关系(P<0.01)。
【Abstract】 To observe the anti-respiratory syncyntial virus effect of a Chinese medicinal herb-Antiviral Agent No.1, we observed the anti-viral effect of Antiviral Agent No. 1 by means of the technique of cell culture using Ribavirin as a positive control. In Hela culture, Antiviral Agent No.1 was found to be a potential inhibitor of respiratory syncyntial virus in a concentration-dependent manner, with a TC50 of 13.9mg/ml, the EC50 (TI) of 0.827mg/ml (16.81); while Ribavirin with a TC50 of 76.43ug/ml, the EC50 (TI) of 5,672ug/ml (13.47).
【Key words】 respiratory syncyntial virus; antiviral effect; Chinese medicinal herb;
- 【文献出处】 黑龙江医药 ,Heilongjiang Medical Journal , 编辑部邮箱 ,2001年04期
- 【分类号】R285
- 【被引频次】2
- 【下载频次】86