【摘要】 目的　探讨铝盐在水中发生的化学反应对铝发育毒性的影响。方法　用全胚胎培养方法比较新配和存放11.5个月的 Al2 (SO4) 3溶液对大鼠胚胎生长发育和器官形态分化的抑制效应。结果　二种受试溶液均表现出一定的胚胎毒性和致畸性 ,但与新配溶液相比 ,存放溶液的毒性明显降低。在同一浓度下 ,给予存放溶液的大鼠其反映胚胎生长发育的各项指标和反映器官形态分化的 Brown总评分 ,以及畸形胚胎发生率和胚胎死亡均明显低于新溶液 ,其中胚胎死亡率下降幅度更大。结论　存放的 Al2 (SO4) 3溶液因 Al3+与水分子发生络合反应使 Al3+的存在状态发生改变 ,使其对大鼠的发育毒性减弱更多还原

【Abstract】 Objective To explore the effects of chemical reaction of aluminum salt in water solution on developmental toxicity Methods Inhibiting actions on embryo growth and development,and organ morphogenetic differentiation in rats induced by newly prepared and 11 5 month stored aluminum sulfate solution were observed and compared using whole embryo culture method in rats Results Both of the two observed solutions showed a certain embryo toxicity and teratogenicity The toxicity of stored solution decreased significantly compared with that of newly prepared solution At the same concentration of aluminum,the total Brown’s morphogenetic score reflecting the every index of embryo growth and development and organ morphogenetic differentiation,the incidence rates of terata and the number of dead embryos were significant lower in rats exposed to stored solution compared with those exposed to newly prepared solution,especially the morbidity of embryos Conclusion The complexation reaction between aluminum ions (Al 3+ ) and water molecules in stored aluminum sulfate solution resulted in the changes of existing state of Al 3+ and its decreasing developmental toxicity to rats更多还原