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甾体微生物转化在制药工业中的应用
Application of microbial steroid transformation in pharmaceutical industry
【摘要】 对几种重要的甾体微生物转化反应如甾体边链降解、甾体羟基化反应的机理及其发展与应用作了概述 ;同时也介绍了固定化微生物细胞、非水溶液中酶催化反应及混合发酵等微生物转化技术在制药工业中的应用
【Abstract】 Some important microbial steroid biotransformations such as side chain cleavage and hydroxylation were reviewed, including their mechanism, development and applications. The applications of microbial cell immobilization, enzymatic catalysis in nonaqueous solvents and mixed culture in pharmaceutical industry were highlighted.
【关键词】 微生物转化;
甾体;
边链降解;
羟化反应;
固定化细胞;
【Key words】 microbial transformation; steroid; side chain cleavage; hydroxylation; cell immobilization;
【Key words】 microbial transformation; steroid; side chain cleavage; hydroxylation; cell immobilization;
- 【文献出处】 工业微生物 ,Industrial Microbiology , 编辑部邮箱 ,2001年04期
- 【分类号】TQ460
- 【被引频次】100
- 【下载频次】1613