【摘要】 目的 :探讨薏苡仁酯 (coixenolide,CXL )对辐射诱导的人鼻咽癌细胞 CNE- 2 Z凋亡的影响。方法 :以 6 0 Co为放射源 ,采用形态学 (荧光染色 )方法和流式细胞术观察 CNE- 2 Z细胞的凋亡和药物作用。结果 :CNE- 2 Z经照射后 ,凋亡细胞数增加 ,并与放射剂量和观察时间成正相关。加入 CXL,可使放射量效曲线和时效曲线左移。流式细胞仪分析也得到相似的结果。辐射也诱导正常细胞凋亡 ,但 CXL并没有加强此作用。结论 :CXL能选择性地促进射线所致的细胞凋亡。更多还原

【Abstract】 objective:To study the effect of coixenolide (CXL) on ind uc ed apoptosis of human nasopharyngeal carcinoma (NPC) cell line CNE 2Z by radiat ion.Methods:Cell apoptosis caused by γ ray was investigated with cell morpholo gy (fluorescence staining) and flow cytometry.Results:Apoptotic CNE 2Z cells in creased after radiation.CXL could shift the radiation dose and time response curves to the left.Similar result was obtained from flow cytometry.Irradiation a lso induced the apoptosis in normal mouse bone marrow cells,but,which was not in fluenced by CXL.Conclusion:CXL can selectively enhance the apoptosis induced by radiation.更多还原