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复方镇痛膏对小鼠镇痛镇定作用的初步研究

Study of Compound Sedative Paste On Analgesic and Sedative Effects

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【作者】 黄如栋薛团梅车苏容苏晓宇林善春

【Author】 HUANG Ru dong\+1,XUE Tuan mei\+2,CHE Su rong\+1,et al\;(1.Dept.of Pharmacy,FCTCM,Fuzhou,Fujian 350003,China; 2.Fu’an Medical Company,Fujian Fu’an 355000,China)

【机构】 福建中医学院药学系福安市医药有限公司福建中医学院药学系 福建福州350003福建福安355000福建福州350003福建福州350003

【摘要】 采用热板法和醋酸扭体法观察了复方镇痛膏对小鼠的镇痛作用 ,采用尾悬挂法和协同阈下剂量水合氯醛催眠的方法观察了对小鼠的镇定作用。结果发现该药明显减少醋酸所致小鼠的扭体次数 ,小幅提高小鼠对热刺激的痛阈 ,显著延长尾悬挂小鼠的不动时间 ,显著提高阈下剂量水合氯醛致小鼠的睡眠率。证明复方镇痛膏具有显著的镇痛镇定作用

【Abstract】 The analgesic effects of compound sedative paste were observed by hot plate and acetic acid inducing writhing models,and the sedative effects were observed by testing the stillness time of tail suspension mice in 6 seconds and noting the number of sleep mice induced by subthreshold doses of choral hydrate.The results showed that the paste could obviously decrease the writhing times,increase the pain threshold for thermal stimulation a little,prolong stillness time of tail suspension mice,and increase the number of sleep mice induced by subthreshold doses of choral hydrate.It indicates that the paste has the analgesic and sedative effects.\;

【关键词】 复方镇痛膏镇定镇痛小鼠
【Key words】 compoud sedative pastesedationanalgeticmice
【基金】 福建省教育厅资助课题 ( JA992 0 4)
  • 【文献出处】 福建中医学院学报 ,Journal of Fujian College of Traditional Chinese Medicine , 编辑部邮箱 ,2001年04期
  • 【分类号】R285.5
  • 【被引频次】2
  • 【下载频次】66
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