【摘要】 目的　探讨HPV1 6/ 1 8E6蛋白和p53、增殖细胞核抗原 (PCNA)蛋白在宫颈鳞癌组织中的表达及相关关系。方法　用免疫组织化学SP法对 36例宫颈鳞癌及 2 8例慢性宫颈炎中的HPV1 6/ 1 8E6蛋白和p53、PCNA蛋白进行检测。结果　宫颈鳞癌中E6和p53、PCNA阳性率均明显高于慢性宫颈炎组 ,并且E6阳性的宫颈鳞癌与慢性宫颈炎p53、PCNA阳性率明显高于E6阴性组。结论　HPV1 6/ 1 8感染及p53、PCNA蛋白的过表达与宫颈鳞癌的发生密切相关 ,至于HPV1 6/ 1 8E6蛋白与p53蛋白之间的内在联系尚有待于进一步研究。更多还原

【Abstract】 Objective To explore human papillomavirus type 16/18 infection and its relationship between p53.PCNA protein expression in human cervical carcinoma. Methods Immunohistochemical method was used to detect HPV16/18 E6 protein and p53.PCNA protein in 36 cases of human cervical carcinoma and 28 cases of chronic cervicitis .Results All of E6 protein while p53 protein and PCNA positive rate in human cervical carcinoma were significantly higher than those in chronic cervicitis while p53 protein and PCNA positive rate in those of E6 protein positive were significantly higher than those of E6 protein negative.Conclusion HPV16/18 and high expression of p53,PCNA are significantly related to human cervical carcinoma while the relationship between HPV16/18 E6 protein and p53 protein remains to be further studied.更多还原