【摘要】 目的　观察长期摄入过量碘对人群垂体－甲状腺功能的影响。方法　选择江苏省徐州高碘病区１７～１８岁学生分为高碘甲肿组及高碘非甲肿组，选择天津１８～１９岁学生为适碘对照组，用放免法测定静脉血清ＴＴ３、ＴＴ４、ＦＴ３、ＦＴ４及ＩＲＭＡ法测定ｓＴＳＨ浓度。结果　高碘病区甲肿及非甲肿学生血清中ｓＴＳＨ明显高于适碘对照组（Ｐ＜０．０１），并且ｓＴＳＨ高于正常值的比例明显增多，高碘地区两组学生的ＴＴ３水平显著升高（Ｐ＜０．０５），但高碘非甲肿组的ＦＴ３较适碘组明显降低，而高碘甲肿组ＦＴ３仅呈降低趋势但无统计学意义（Ｐ＞０．０５）。三组间ＴＴ４及ＦＴ４差异无统计学意义（Ｐ＞０．０５）。结论　长期摄入过量碘导致人群亚临床甲低。更多还原

【Abstract】 Objective To observe the influence on pituitary and thyroid function by high iodine intake in human being. Mehods The target group,aged 17-18 years, from high iodine area including high iodine goiter and no-goi-ter studente was compared with the control group, aged 18-19 years,from adequate iodine area. Serum TT4,TT3,FT4 and FT3 were determined by RIA and TSH by IRMA. Results TSH in two groups from high iodine area was remarkably higher than the group from adequate iodine area(P < 0.01)nd the percent the percent of subjects whose TSH were higher than normal range was also greatly higher. TT3 of both high iodine groups was higher than adequate group(P < 0.05), meanwhile the percent of subjects whose TT3 were higher than normal range was increased greatly. Although FT3 of all individuals was tested within normal range, FT3 in no-goiter group from high iodine area declined significatly com- pared with iodine iodine ( P < 0.05) while the high iodine goiter group showed the decreasing trend without statistical significance(P >0.05). TT4 and FT4 showed no difference among three groups(P >0.05).Conclusion Long-term high iodine diet may induce subclinical hypothyroidism.更多还原