【摘要】 目的　本研究拟查明 1998年华东地区一种与病死猪有接触史的人的急性传染病病原体的生物学特征与疾病流行的关系。方法　流行病学调查 ,并对病死猪及死亡患者进行病理检查 ,分离病原及其实验研究。结果　该病具有起病急、病情重、病程短、病死率高等特点。临床及病理表现为 :起病多似感冒有高热、四肢疼痛、有时有呕吐、腹泻等 ,迅速发展为肌炎、筋膜炎、DIC、多脏器功能衰竭、休克 ,多于 2～ 3d内死亡。 2 5例患者中 ,临床表现为中毒性休克综合征的 16例 ,链球菌性脑膜脑炎综合征的 9例 ,两者的病死率分别为 81.2 5 %和 11.11%。从猪和病人标本分离的病原体 ,其形态、染色性、生物学特征均一致。结论　患者血和病猪脏器中分离的病原菌鉴定结果证明两者均为链球菌。更多还原

【Abstract】 Objective To reveal the relationship between the biological characteristics of pathogen and the spread of disease of an epidemic related to infectious disease of pig in 1998 in East China. Methods Epidemiological survey pathological examination of pigs and patients, and pathogen isolation were performed. Results The disease had a character of quick onset, serious symptoms, short course and high mortality. The clinical manifestations and patholgical changes of the disease were high fever, sometimes with nausea, vomiting and diarrhea, then might developed to myositis, fascitis, DIC, multiple organ failure, shock and usually died in 2～3 days. Among 25 patients, 16 manifested clinically as streptococcal toxic shock syndromes (STSS) and 9 streptococcal meningocephalitis syndrome, The mortality was 81.25% and 11.11% respectively. Pathogenic bacteria isolated from diseased pigs and patients were found to have some common characteristics in morphology, staining and biological characters. Conclusion The pathogen isotaled from the blood of patients and pigs were identified as the streptococci.更多还原