【摘要】 目的　研究口腔临床常用抗菌药物对牙周炎主要病原菌牙龈卟啉单胞菌 (Pg)的抗菌活性。方法　用从成人牙周炎患者龈下菌斑中分离的、通过PCR鉴定的 1 0 6株Pg临床分离株 ,采用琼脂稀释法测定了甲硝唑、克林霉素和替硝唑对三种不同浓度Pg菌液的最小抑菌浓度 (MIC)。结果　上述药物对Pg的MIC范围依次是 0 .2 5 8mg/L , 0 .0 6 8mg/L和 0 .0 6 4mg/L ;MIC90 依次为 8mg/L ,8mg/L和 4mg/L。 1 0 5 CFU/ml,1 0 6 CFU/ml和 1 0 8CFU/ml三种菌液浓度对实验结果无明显影响。结论　Pg对这三种药都非常敏感 ,敏感性大小依次为替硝唑、克林霉素和甲硝唑更多还原

【Abstract】 Objective Porphyromonas gingivalis(Pg)is one of the main putative pathogens of periodontal disease,espcially of adult periodontitis.This in vitro study was aimed at observing the inhibition actions of 3 kinds of antimicrobial drugs on Pg.Methods 106 stains of Pg were isolated from subgingival plaques with adult periodontitis.The agar diffusion test was used to detect the inhibition actions of metronidazole,clindamycin and tinidazole on 106 stains of Pg.Results Their MIC was respectively:0.25mg/L,0.6mg/L.The MIC 90 of tinidazole<MIC 90 of clindamycin.The results showed:all of metroidazole,tinidazole and clindamycin can be used effectively against Pg,clindamycin and tinidazole showed more potent antibacterial activity than metronidazole.The different concentration of Pg liquid (10 5CFU/ml,10 6CFU/ml and 10 8CFU/ml) had not influenced the results.Couclusion This study is significant to antibiotical therapy of periodontal diseases.更多还原