【摘要】 目的　 探讨皮质醇的动态变化与哮喘病人夜间加重或发作的关系。方法 :检测夜间哮喘病人急性发作期、缓解期和健康对照组血浆中皮质醇早晨 4时与下午 4时含量的变化及与峰值流速 (PEF)变化的相关性。结果 :从未用糖皮质激素治疗的急性发作期病人皮质醇的含量与健康对照组相比差异无显著性 ,缓解期病人的皮质醇含量较急性发作期和健康人明显减低 ,且缺乏动态变化规律。结论 :从未用糖皮质激素治疗的哮喘病人有与健康对照组相同的糖皮质激素水平和昼夜变化节律 ,因此哮喘病人夜间加重不是由皮质醇水平降低而致。缓解期病人的皮质醇含量低及缺乏昼夜变化节律可能是全身应用糖皮质激素的结果。更多还原

【Abstract】 Objective:To explore the relationship between the circadian variation of cortisone and the pathogenesis of nocturnal asthma.Methods: Blood levels of cortisone and PEF were measured during acute exacerbation in 30 nocturnal asthmatic patients (not treated with glucocorticoid,during stabilization in 30 asthmatic ptaients,and at 4 AM and 4 PM in 30 normal control subjects.Results: There was normal level and circadian rhythm of cortisone during acute exacerbation in nocturnal asthmatic patients when compared with control group ( P >0 05).Conclusion:Nocturnal worsening symptoms of asthma could not be caused by reduction of serum cotisone concentration.更多还原