【摘要】 了解腹膜透析患者的骨代谢状况。用IRMA、RRA和RIA对 2 4例持续不卧床腹膜透析 (CAPD)患者测定血清PTH(1- 84)、2 5 (OH)D3 、1,2 5 (OH) 2 D3 、BGP以及血Ca和P的变化。结果表明 :尿毒症患者PTH和BGP升高 ,CAPD可以使其降低 ;2 5 (OH)D3 和 1,2 5 (OH) 2 D3 降低 ,CAPD对其无明显影响 ;PTH与 2 5 (OH)D3 、1,2 5 (OH) 2 D3 呈负相关 ,P分别小于 0 .0 5和 0 .0 1;PTH与BGP呈正相关 (P <0 .0 1) ,CAPD可使其相关性降低。提示PTH分泌亢进是骨代谢紊乱的主要因素之一 ,CAPD患者骨转化率降低更多还原

【Abstract】 Bone metabolism in patients with chronic renal failure treated by continuous ambulatory peritoneal dialysis(CAPD) was evaluated. IRMA, RRA and RIA were used to detect PTH, 25(OH)D 3,1,25(OH) 2D 3,BGP,Ca and P levels in the blood of 24 CAPD patients. PTH and BGP were increased in uremic patients and decreased after CAPD. 25(OH)D 3 and 1,25(OH) 2D 3 were decreased in the patients, but their levels were not changed further after CAPD. PTH had negative correlation with 25(OH)D 3( r =-0.379, P < 0.05 ) and 1,25 (OH) 2D 3 ( r =-0.451, P <0.01).PTH had positive correlation with BGP ( r =0.501, P <0.01)in CAPD patients, and the correlativity was decreased by CAPD. The results showed: PTH hypersecretion is a main factor inducing bone metabolism disturbance, and bone turnover rate is decreased in these patients by CAPD.更多还原