【摘要】 目的 :探讨阵发性非瓣膜病心房颤动患者内皮纤溶储备功能以及全身纤溶状态的变化规律。方法 :测定2 7例阵发性非瓣膜病房颤患者的全套纤溶指标 ,并与 19例正常人对比。同时做静脉闭塞试验以确定最大内皮组织纤溶酶原激活剂 (t -PA)释放。结果 :阵发性非瓣膜病房颤患者t -PA活性 ,PIg明显下降 ,而PAI— 1活性增高 ,最大内皮t -PA释放明显降低。结论 :阵发性非瓣膜病心房颤动患者存在明显的低纤溶状态 ,同时伴有内皮纤溶储备功能的下降。更多还原

【Abstract】 Objective:To explore the altered regularity of the fibrinolytic system and the endothelial fibrinolytic reserve capacity in non-rheumatic patients with paroxysmal atrial fibrillation Metheds:Venous blood was sampled for determination of fibrinolytic ststem at admission in 27 patients with paroxymal atrial fibrillation and compared with 19 normal subjcts,an occlusion test to determine the maximal endothelial tissue plasminogen(t-PA)release was perfored Results:It was found that patient with paroxysmal atrial fibrillation showed significantly lower activity t-PA and higher activity PAI-1 than control,maximal endothelial t-PA release was initially reduced Conclusion:The non-rheumatic patient with paroxysmal atrial fibrillation shows hypofibrinolytic state Endothelial fibrinolytic reserve capacity is reduced更多还原