【摘要】 目的　在染色体 17p13.3杂合性缺失区域内进行表达序列的分离。方法　采用外显子搏获法对位于 17p13.3杂合性缺失区域内的 BAC基因组克隆进行外显子的分离。结果　在获得的克隆中 ,4个克隆为已知基因的外显子 ,另 4个克隆属于 3个新外显子 (2个克隆中的外显子片段序列一致 )。结论　在染色体 17p13.3杂合性缺失区域内获得了一些表达序列。更多还原

【Abstract】 Objective Isolation of expression sequence on the Loss of Heterozygosity (LOH) region on chromosome 17p13 3 was caried out.Methods Exon trapping.Results Eight exons were isolated ,4 of them are exons of known genes and the others are novel.Conclusion Some exons on the LOH region of chromosome 17p13 3 were obtained.$$$$更多还原