【摘要】 目的 检测嗜铬粒蛋白Ａ（ＣｇＡ）在前列腺癌组织中的表达。方法 采用免疫组化技术观察ＣｇＡ、神经特异性烯醇化酶（ＮＳＥ）、生长抑素（ＳＳ）及降钙素（ＣＴ）在３０例前列腺癌和２０例前列腺增生症组织中的表达。结果 ＣｇＡ在前列腺癌和前列腺增生症标本中的表达率分别为６０％和２５％，两者有显著性差异（Ｐ＜０．００１）。明显高于生长抑素（ＳＳ）、降钙素（ＣＴ）免疫组化染色和常用的Ｃｒｉｍｅｌｉｕｓ嗜银染色的表达率，与神经特异性烯醇化酶（ＮＳＥ）表达率无显著性差异。结论 ＣｇＡ是前列腺癌组织中ＮＥ细胞最敏感的标记物，ＣｇＡ免疫组化染色可作为检测前列腺癌组织中神经内分泌细胞及分化的一种可靠的方法。更多还原

【Abstract】 Objective The expression of chromograninA (CgA) in prostatic carcinoma (PCa) was studied. Methods The samples of 30 cases with PCa and 20 cases with benign prostatic hyperplasia (BPH) were examined using immunohistochemical staining with CgA, neuron-specific antigen (NSE), somatostatin (SS) and calcitonin (CT) antisera. Results The expression of CgA in PCa and BPH was 60%(18/30) and 25%(5/20) respectively and significantly higher than that of somatostatin (SS), calcitonin (CT) and the Grimelius staining. There have no significant difference between CgA and NSE Immunohistochemical staining, but CgA positive cells showed clear neurosecretory-type granule. Conclusion CgA may be a useful marker for the determination of the neuroendocrine (NE) cells and differentiation in prostatic carcinoma.更多还原