【摘要】 目的　探讨 5 Fu合并抗生素泰能区域动脉灌注 (regionalarterialinfusion ,RAI)能否降低急性坏死性胰腺炎 (ANP)感染和死亡率。方法　选择ANP 5 3例 ,分为A、B、C组。A组 16例 ,静脉途径给予 5 Fu及泰能 ;B组 2 2例 ,RAI途径给予 5 Fu ,静脉给予泰能 ;C组 15例 ,RAI途径交替使用 5 Fu和泰能。结果　C组感染率 (0 )明显低于A组(5 0 .0 % )和B组 (2 7.3 % ) ,P <0 .0 0 1,P <0 .0 1;B、C两组死亡率分别为 18.2 %和 13 .3 % ,均明显低于A组 (43 .8% ) ,P <0 .0 5。结论　RAI途径应用 5 Fu合并泰能能有效降低ANP感染及死亡率。更多还原

【Abstract】 Objective To determine whether regional arterial infusion (RAI) of 5-Fu and imipenem could decrease infection and mortality of acute necrotic pancreatitis (ANP) or not. Methods Fifty three patients with ANP were devided into three groups, group A, 16 patients who received intravenous 5-Fu and imipenem, group B, 22 patients who received 5-Fu by RAI and imipenem intravenously, and group C, 15 patients who received both 5-Fu and imipenem by RAI. Results The incidence of infection of ANP in group C (0%) was significantly lower than that in group A (50.0%) and B (27.2%), and the mortality rates in group B (18.1%) and C (13.3%) were significantly reduced as compared with group C (43.8%). Conclusion RAI of 5-Fu and imipenem was effective in reducing ANP infection and mortality rates.更多还原