【摘要】 泰乐星提炼过程中原工艺脱色液用薄膜真空浓缩 ,本试验改进为耐溶媒纳滤膜浓缩 ,料液不需要加热即可浓缩 ,防止了料液的高温分解破坏 ,浓缩收率明显提高 ;在浓缩的同时 ,部分小分子杂质可以随水分子一起通过纳滤膜而除掉 ,成品质量明显提高 ,解决了用原工艺成品酪胺、溶解度不合格的质量问题 ;省去了原工艺浓缩中费用较高的蒸汽、冰盐水 ,经济效益可观。现纳滤工艺已成功地运用到泰乐星大生产中。更多还原

【Abstract】 The method of concentrating the decoloration solution of tylosin is usually carried out by thin film vacuum concentration. In this experiment, the concentration process is modified by using the nanofiltration membrane technique which is free from corrosive due to the extractant solvent and in the same time, heating and decomposition of the antibiotic are eliminated, the concentration course ia also distinctly shortened. In this process the small molecule can be filtered by water, and the quality of the product such as, the tyramine content, the solubility of the product, improved significantly. In addition, the membrane filtration process could save consumption of steam and cooling water. This process has now been applied in the mass production of tylosin in our plant.更多还原