【摘要】 目的　探索精神分裂症患者血清中的病理活性因子。方法　将精神分裂症患者 (10例 )血清与健康人淋巴细胞混合培养 ,观察淋巴细胞c fos基因蛋白的表达情况 ,用自动琼脂糖电泳分析仪检测血清蛋白 ;同时设立内科疾病组 (10例 )及健康人组 (2 4名 )对照做上述试验。结果　在 7 10的精神分裂症患者血清中检出c fos基因蛋白表达诱导因子 ,在内科疾病人组及健康人组中则未检出该因子。精神分裂症组与上述两个对照组之间差异均有非常显著性 (P <0 0 1)。血清蛋白电泳结果表明 :精神分裂症组血清蛋白具有明显的特征性改变 ,与对照组比较差异有非常显著性 (P <0 0 1)。结论　精神分裂症患者血清中有一种促c fos基因蛋白表达的因子 ,其生物活性可能与精神分裂症的病理机制密切相关。更多还原

【Abstract】 Objective The aim of the paper was to explore pathological factor in schizophrenia Methods The lymphocyte of health individual was cultured with serum of schizophrenia The expression of c fos gene protein was observed with immunohistochemistry The protein in serum was analyzed with agarose autoelectrophoresis instrument Control group, internal medicine diseases and health individual, was established Results A factor in serum, which induced superexpressing c fos in lymphocyte, was detected in 7/10 schizophrenia and not detected in control group There was a significant difference between two groups ( P <0 01) The electrophoresis result showed that characteristic change was obtained with multivariate analysis There was also a significant difference between groups( P <0 01) Conclusion There may be a factor that induced superexpressing c fos in schizophrenic serum and related with schizophrenic pathology更多还原