【摘要】 目的　观察转化生长因子 β1(transforminggrowthfactor β1,TGF β1)对鼠牙槽骨缺损修复的诱导作用。方法　将 2 0只实验小白鼠随机分为实验组和对照组 ,在两组动物 1| 1牙间牙槽骨人工制备 2mm× 2 5mm骨缺损区 ,实验组骨缺损区填入浸有TGF β1溶液的明胶海绵块 ,对照组只填入明胶海绵块。术后 1、2周及 1、3个月分别处死动物 ,进行组织学观察。结果　①实验组 :术后 1周 ,骨缺损区周围有炎性细胞浸润 ,可见牙槽骨变性坏死 ;术后 2周 ,炎性渗出明显吸收 ,成纤维细胞、毛细血管生长活跃 ,可见骨样组织和少量骨组织 ;术后 1～ 3个月 ,新生骨组织范围扩大 ,钙化程度加强。②对照组 :术后 1周 ,骨缺损区周围有大量炎性细胞浸润 ;术后 2周 ,炎性渗出吸收 ,成纤维细胞、毛细血管生长活跃 ;术后 1个月 ,骨缺损区周围有成骨细胞 ;术后 3个月 ,骨缺损边缘有少量新骨沉积。结论　TGF β1可诱导牙槽骨再生更多还原

【Abstract】 Objective To study the induction of transforming growth factor β 1(TGF β 1) in reparative process of mouse experimental alveolar bone defect Methods Alveolar bone defect were made in 20 mice at 1｜1 region In twelve mice (experimental group),the defect was filled with gelatin sponge infiltrated by TGF β 1 solution; in eight mice (control group), the defect was filled with gelatin sponge The peripheral tissue coating alveolar bone defect was harvested for histopathologic study after 1 week, 2 weeks and 1 month, 3 months Results The main histopathologic changes were:① experimental group: inflammatory cell infiltration (1W); inflammatory cell disappearance, fibroblast and capillary tachyauxesis, osteoid tissue and small amount neoformative bone tissue appearance (2 W); fibrous tissue decrease, neoformative bone tissue enlarging and maturity (1～3 M) ② control group: inflammatory cell infiltration (1W); inflammatory cell disappearance, fibroblast and capillary tachyauxesis (2W); osteoblast appearance around bone defect (1M); small amount neoformative bone tissue around bone defect Conclusion TGF β 1 can induce alveolar bone regeneration更多还原