【摘要】 目的　探讨疏波和密波短声诱发的动作电位 (actionpotential,AP)潜伏期差对梅尼埃病的诊断价值。方法　采用鼓膜电极耳蜗电图描记术 ,对 5 0例正常听力耳和不同听力损失程度和听力图类型的梅尼埃病 90耳及其他原因感音神经性聋 6 0耳分别记录了疏波和密波短声AP潜伏期 ,并对其计算得出的差值进行分析。结果　梅尼埃病组疏波和密波短声诱发的AP潜伏期差 (0 30± 0 15 )ms( x±s,下同 )明显高于正常对照组 (0 18± 0 0 7)ms和其他感音神经性聋组 (0 2 0± 0 10 )ms ,(P值均 <0 0 1) ;梅尼埃病组轻度和中度聋组AP潜伏期差高于中重度聋组 (P <0 0 1) ;低频型和高频型患者高于平坦型 (P <0 0 1)。正常组和其他感音神经性聋组比较差异无显著性意义。感音神经性聋组AP潜伏期差异常率为 4/6 0 (6 7% ) ,梅尼埃病组 5 8/90 (6 4 0 % )。结论　梅尼埃病患者中疏波和密波短声诱发的AP潜伏期差可出现异常增大 ,这一客观参数可能有助于临床诊断更多还原

【Abstract】 Objective To study the value of condensation and rarefaction clicks evoked action potential(AP) latency difference( LD) in diagnosis of Meniere′s disease Methods AP was recorded with ECochG in controls (50 ears)and patients with Meniere′s disease(90 ears) and sensorineural hearing loss(SNHL)of other origins(60 ears) LD was calculated and analyzed Results LD in patients with Meniere′s disease was (0 30±0 15) ms, which was significantly larger than that of controls(0 18 ± 0 07) ms and of patients with SNHL of other origins(0 20±0 10) ms ( P <0 01). In the group of Meniere′s disease, LD in patients with the mild and moderate hearing impairment was larger than those with severe hearing loss( P <0 01) and LD in patients with low tone or high tone auditory sensation curve was larger than those with flat auditory sensation curve( P <0 01) Positive rate was 4/60(6 7%) in other SNHL patients and 58/90(64 0%) in Meniere′s disease group respectively Conclusion The increase in condensation and rarefaction click evoked AP latency difference can be an objective parameter in diagnosis of Meniere′s disease更多还原