【摘要】 目的 :观察益母草水煎液对大鼠子宫肌电活动的影响并探讨其机理。方法 :在大鼠一侧子宫浆膜表面埋埴一对Ag AgCl双极电极并联机记录。分别给其腹腔内注射益母草水煎液 0 .1ml,0 .2ml及 0 .4ml,对大鼠子宫肌电活动的变化进行慢性实验观察。结果 :在注药后 ,大鼠子宫肌电的慢波频率加快、平均振幅增大 ;单波频率加快、最大振幅增大 ;爆发波时程延长、串间隔缩小、最大振幅增大 ,并与剂量有关。结论 :益母草对子宫的兴奋作用可能是通过改变了与电活动有关的一些离子浓度 ,使起步细胞电活动加强及动作电位去极化速度加快所致。更多还原

【Abstract】 Objective:To investigate the effect of motherwort herb on the myoelectric activity of uterus in rats.Method:A pair of bipolar Ag AgCl electrode was implanted on the serosal surface of the uterus in rats,motherwort herb was injected intra abdominal cavity in rats in dose of 0.1 ml, 0.2 ml and 0.4 ml respectively, and the changes of uterine myoelectric activity were observed.Result:Motherwort herb significantly increased the frequency and average amplitude of uterus slow waves of in rats.The frequency and maximum amplitude of single waves also obviously increased.The time course of outbreak waves was prolonged,the series intervals were reduced and the maximum amplitude in each outbreak was increased.Conclusion:The exciting effect of motherwort herb on the uterine smooth muscle may have something to do with the alteration of the ion concentration in relation to myoelectric activity, resulting in the increase of myoelectric activity of pacesetter cells as well as in the acceleration of depolarization of spike activity. [更多还原