【摘要】 目的　在体研究降钙素对成年雄性大鼠松质骨重建过程的影响 ,并分析其影响机制。方法　12只大鼠平均分成对照组和降钙素组 ,后者皮内注射鳗鱼降钙素 1U/ 10 0 g/日 ,连续 2日。 7日后取第4、5腰椎 ,行不脱钙骨组织切片 ,骨组织形态计量学分析 ,方差分析比较两组结果。结果　骨吸收陷窝表面、活性吸收表面、破骨细胞平均细胞核数 ,降钙素组明显小于对照组。类骨质表面、类骨质相对体积、类骨质厚度 ,降钙素组明显小于对照组 ,成骨细胞形态两组之间有显著差异。骨小梁相对体积 ,两组之间无差异。结论　降钙素对正常成年雄性大鼠松质骨而言 ,可以明显抑制破骨吸收 ,这种作用可能是通过减少活性吸收表面数量和降低破骨细胞的吸收功能来完成的 ;可以抑制成骨细胞形成类骨质的活性 ,这种作用可能不是直接的 ,而是通过降钙素对骨吸收的抑制作用进而影响了骨吸收与骨形成的之间的偶联而完成的 ;短期应用降钙素骨量无变化更多还原

【Abstract】 Objective\ The effect of calcitonin on bone remodeling of adult male Wistar rat was observed and the mechanism was analyzed.Methods\ Twelve rats were distributed randomly to control and calcitonin groups.The rats in calcitonin group were administered elatonin(1U/100g/day,2days).The fourth and fifth lumbar vertebral bodies were undecalcified and analyzed by histomorphometry.T test was used to analyze the differences between the two groups.Results The eroded surface,active resorptive surface,nuclear number of osteoclasts in calcitonin group were less than in control group.The osteoid surface,osteoid volume,osteoid thickness in calcitonin group were less than in control group.There was significant difference in osteoblast appearance between calcitonin and control groups.There is no difference of trabecular volume between calcitonin and control group. Conclusion For normal adult male rat,calcitonin depresses the osteoclastic resorption obviously through reducing the number of active resorptive surface and depressing osteoclastic activity;on the other hand,calcitonin depresses the osteoid producing activity of osteoblasts by indirectly affecting the coupling process between resorption and formation.Calcitonin administered in short did not affect the bone volume.更多还原