【摘要】 目的　研究p16基因缺失与原发性食管鳞癌的相关性。方法　采用PCR方法检测 41例原发性食管鳞癌组织中p16基因的缺失情况。结果　 41例食管鳞癌组织有 6例p16基因缺失 ,缺失率为 14 .6%。低分化食管癌p16基因缺失率为 5 0 % ,高于中分化 (p =0 .0 0 0 9)和高分化食管癌 (p =0 .0 2 2 )。有淋巴结转移缺失率高于无淋巴结转移 (p =0 .0 0 3 )。结论　p16基因缺失与食管鳞癌的发生发展有相关性。更多还原

【Abstract】 ? Objective To study the relationship between deletion of p16 gene and primary human esophageal carcinoma.Methods A total of 41 human esophageal squamous cell carcinoma specimens were examined for homozygous deletion of p16 gene using PCR method.Results The homozygous deletion of p16 gene was confirmed by PCR in 6 cases,with a rate of 14.6%.Compared to high or mild differentiated cancer,the homozygous deletion of p16 gene was higher in lower defferentiated cancer.The homozygous deletion of p16 gene was higher in the cases with lymphatic metastasis than in those without lymphatic metastasis.Conclusions The homozygous deletion of p16 gene is correlated with the progression of primary human esophageal carcinoma. 〔更多还原