【摘要】 目的 研究脑损伤后白细胞介素-6(IL-6)的变化及对急性反应期的作用。方法 用酶联免疫法(ELISA)和酶标仪测定创伤性脑损伤后脑脊液和血清IL-6的连续变化及测定急性反应蛋白的变化。结果 正常对照组脑脊液中均未能检测到IL-6,重型创伤脑损伤后脑脊液和血清IL-6均升高,且脑脊液IL-6较血清的IL-6明显升高。在血脑屏障功能严重障碍时脑脊液的IL-6与血清的IL-6相关。血清IL-6的最大值与急性反应蛋白(CRP)及纤维蛋白原的峰值相关。结论 脑损伤后脑脊液和血清中IL-6明显升高,血清IL-6可能是脑脊液中的IL-6转移来的。中枢神经系统产生的IL-6在脑创伤的急性反应期可能起到始动作用。更多还原

【Abstract】 Objective To study the variations of interleukin-6 (IL-6) in serum and cerebrospinal fluid( CSF) of patients following severe brain injuries. Method Clinical data obtained from 15 patients with severe traumatic brain injuries were analyzed to evaluate the characteristic changes of IL- 6 levels being related to brain injury. Data from 6 patients without any neurological di-orders served as control. Results IL - 6 was not detected in samples from control group but it was found and obviouly increased both in the serum and CSF in the patients with severe brain injury. The increase in IL - 6 level was more marked in CSF than that in the serum, and was closely correlated with the severity of the injury. Conclusions The IL-6 level both in the CSF and serum was significantly increased in patients with severe brain injury. The IL - 6 level in the CFS was positively correlated with that in the serum when the functions of blood-brain barrier were seriouly impaired. The IL- 6 produced in the central nerve system probably played an important role in initiating the acute reactive phase following severe traumatic brain injury.更多还原