【摘要】 观察乙型肝炎 (乙肝 )血源疫苗新生儿期接种 9～ 10年后 ,疫苗诱导抗体转阴者是否仍对乙肝表面抗原 (HBsAg)保持免疫记忆。采用RIA方法测定并比较乙肝疫苗加强免疫(加免 )前后受试对象的抗 HBs水平。结果 48名受试儿童加免后 1个月 ,抗 HBs阳性率与滴度均明显高于免前 (p <0 0 1) ,70 9% (34 /4 8)的加免儿童保持免疫记忆 ,持续时间至少已 3年。提示 3针 10 μg乙肝血源疫苗新生儿期接种 9～ 10年后 ,大部分诱导免疫抗体阴转的免疫儿童保持着免疫记忆。初免后 10年仍未见有加强免疫的必要更多还原

【Abstract】 To observe immunologic memory for HBsAg among vaccinees with vaccine induced anti HBs negative-conversion 9～10 years after infancy plasma derived hepatitis B vaccine immunization.Methods\ RIA was used to exame and compare the anti HBs levels of subjects between hepatitis B vaccine pre and post booster.Results\ Anti HBs positive rate and titer of 48 subjects after booster were significantly higher than that before booster(P<0 01);70 9%(34/48) of subjects kept immunologic memory which had at least persisted 3 years.Conclusion Majority of children who were vaccine induce anti HBs negative conversion vaccinated had kept immunologic memory and no evidence for need to booster,9～10 years after three doses of hepatitis B vaccine immunization in infancy.更多还原