【摘要】 为了探讨大鼠染尘后血液中NO含量和NOS、GSH PX的活性在体内的变化以及一些抗氧化剂对测量指标的影响 ,检测血液中NO含量及NOS活性、GSH PX活性。结果显示 :大鼠染尘后 ,血液中NO含量、NOS活性明显上升。GSH PX活性却呈显著下降的趋势。应用茶多酚联合VC、VE 处理30天、90天后 ,血液中NO含量与NOS活性显著下降 ,GSH PX活性明显上升。结果表明 :应用茶多酚联合维生素E和维生素C可以提高体内抗氧化酶的活性 ,降低血液中一氧化氮的水平更多还原

【Abstract】 To explore the changes of nitric oxide(NO),nitric oxide synthase(NOS) and glutathione perxidase(GSH Px) of blood following intratraxheal instillation of silica in rats and the effect of tea polyphneols(TP)combined with Vit C,Vit E on those biochemical indexes of rats induced by silica.Methods The contents of NO NOS and GSH Px activities in blood of experimental rats were measured.Results Compared with the physiological saline group,the average content of NO,NOS of the silica group increased (P<0 05).The change of GSH Px activities were a gradual decreased tendency.TP combined with Vit C,Vit E that used to treated the experimental silicosis rats could effectively decrease the level of NO NOS and increase the activities of GSH Px.Conclusion TP combined with Vit C or Vit E can alleviate the abnormal metabolism of NO NOS in rats induced by silica.更多还原