【摘要】 目的 :观察低剂量 5 氟尿嘧啶 /顺铂联合方案持续输注治疗晚期胃癌的近期疗效及毒副反应。方法 :2 1例晚期胃癌予以 5 氟尿嘧啶 /顺铂方法治疗 ,5 氟尿嘧啶 0 2 5 /m2 /d、顺铂 6mg/m2 /d通过微量注射器深静脉持续性输注 2 1h ,连续应用 2 4d为 1疗程 ,休息 10d后重复 ,2疗程及以上评定疗效及毒副作用。结果 :2 1例晚期胃癌中 ,CR 2例 (9 5 % )、PR 10例 (4 7 6 % )、CR +PR 5 7 1% ,毒副作用为白细胞减少 ,血小板减少 ,恶性呕吐及粘膜炎 ,未出现Ⅲ度以上毒副反应。结论 :以生物化学修饰剂作为基础的 5 FU/DDP联合疗法 ,其临床近期疗效高 ,毒副作用低 ,有可能成为晚期胃癌的标准方案之一。更多还原

【Abstract】 Purpose:To evaluate the efficacy and toxicity of the low dose 5 Fluorouracil and Cisplatin continuous infusion for treatment of advanced gastric carcinoma. Methods:A total of 21 patients were enrolled in the trial, FP therapy consisted of 5 FU (0 25/m 2/d) every day by continuous infusion and cisplatin (6 mg/m 2/d) every day by continuous infusion for 3 weeks.Results:A complete response was observed in 2 cases and a partial response in 10 cases, for and overall response rate of 57.1%. Toxic effects included leukopenia, thrombocytopenia, nauesa and vomiting.Conclusions:FP therapy is a promising regimen for patients with advanced gastric carcinoma.更多还原