【摘要】 采用 ig脂肪乳剂法复制大鼠高脂血症模型 ,观测山丹芍药汤全方水煎剂及其不同提取部位对大鼠血清中血脂水平的影响 ,结合药理实验对其活性部位进行追踪和评价 ,并以 TL C法初步分析有效化学成分。结果表明 :山丹芍药汤能显著降低实验性高脂血症大鼠血清 TC、TG及 L DL- C,并可升高 HDL- C;活性部位为醇溶部位 ,主要有效化学成分为黄酮类、酚类和有机酸等化合物。提示山丹芍药汤具有明显调血脂作用 ,其药效是多种有效成分通过多途径协同作用的综合结果更多还原

【Abstract】 The blood lipid regulation effects of Shandanshaoyao Tang (CSPD), a decoction of the Chinese traditional prescription containing Fructus Crataegi, Radix Salviae Miltiorrhizae and Radix Paeoniae Rubra on experimental hyperlipidemic rats and tracing of its active fraction were studied Hyperlipidemic rat models were prepared by ig high cholesterol emulsion. Changes in blood lipid levels after ig CSPD and various fractions of the decoction extract were determined The active fractions were assessed by pharmacological tracing and the active constituents were analyzed by TLC The results showed that CSPD can significantly lower the levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL C), while increase the level of high density lipoprotein cholesterol (HDL C) of hyperlipidemic rats The ethanol soluble fraction was observed to be the main pharmacological active fraction The main active constituents are flavonoids, phenols and organic acids These results suggested that CSPD has significant blood lipid regulation effects on hyperlipidemic rats resulting from the synergic actions of its active constituents更多还原