【摘要】 本文以血小板激活因子（ＰＡＦ）和二磷酸腺苷（ＡＤＰ）诱导的血小板聚集试验为检测指标，追踪观测了中草药槲寄生对ＰＡＦ和 ＡＤＰ诱导的血小板聚集的影响。从槲寄生乙酸乙酯提取物中分离得到的化合物高圣草素 ７－Ｏ－β－Ｄ－葡萄糖苷，体外试验证实对ＰＡＦ诱导的血小板聚集有明显的抑制作用，而对ＡＤＰ诱导的血小板聚集无显著性抑制作用。提示高圣草素７－Ｏ－β－Ｄ－葡萄糖苷是槲寄生抗ＰＡＦ的有效活性成分。更多还原

【Abstract】 A novel natural platelet-activating factor (PAF) antagonist was isolated from a Chinese medicinal. herb Viscum coloratum and its structure was identified as ho moeriodictyol-7-O-β -D-glycoside, which existed in ethyl acetate extract fraction. At the final concentration of 10~-5 mol.L~-1, it could significantly inhibit human and rabbit platelet aggregation induced by PAF, with IC50 being 8.0xl0~-7 mol.L~-1, but had no inhibitory effect on platelet aggregation induced by ADP更多还原