【摘要】 通过量化手段确定各种基本病理变化在肝病诊断中的价值 ,建立肝组织病理活动性量化诊断标准及坐标系。方法　选取基本病理变化各 11项分别作为诊断的急性和慢性指标 ,每项指标均赋于一定分值和级差 ,各单项分值叠加分别得出肝组织急性活动性指数和肝组织慢性活动性指数 ,以慢性分值为横坐标 ,急性分值为纵坐标建立坐标系。对 10 0 8例各类肝病进行评价并与常规读片及Knodell HAI对比观察。结果行方差分析及 q检验。 结果　急重肝、亚重肝、慢重肝的HAAI分值分别为 43 .5 6± 9.0 8,5 1.6 3± 12 .13和 6 5 .45± 17.5 1(P <0 .0 1) ;轻、中、重度慢性肝炎的HCAI分别为 13 .2 5± 6 .90 ,40 .2 9± 10 .99和 5 0 .0 2± 9.78(P <0 .0 1)。静止性肝硬变与活动性肝硬变的HAAI分别为 31.17± 9.0 7和 6 4.96± 16 .6 0 (P <0 .0 1)。随机抽取的 12 0例肝标本 ,诊断总符合率达 6 6 .6 6 %～ 10 0 %。结论　该标准应用方便 ,诊断准确 ,重复性强 ,具有良好的区别性。更多还原

【Abstract】 Objective To evaluate the diagnostic values of characteristic pathologic changes in the liver biopsy specimens,and to develop a numerical scoring diagnostic standard and coordinates system.Method 11 categories of charateristic pathologic lesions that often appeared in acute hepatitis,as so 11 categories in chronic hepatitis were chosen.Each of them was graded to 3 scales,then the essential score and scale score were set up.Adding up to all the numerical scores of individual components,formed the total scores of histological chronic activity index(HCAI) and histological acute activity index(HAAI),using HCAI as transverse coordinates and HAAI as vertical coordinates,coordinates system was set up.1008 patients with various liver diseases were studied,and compared with conventional readings and KnodellHAI. F analysis and q test were carried on.Results The HAAI of acute,subacute,and chronic severe hepatitis was 43.56±9.08,51.63±12.13,and 65.45±17.51 respectively.There was significant difference between each other( P <0.01).HCAI of them was 13.25±6.90,40.29±10.99,and 50.02±9.78 respectively.There was also significant difference( P <0.01).The HAAI of active liver cirrhosis and silent cirrhosis was 64.96±16.60 and 31.17±9.07 respectively.There was significant difference( P <0.01).The tolal diagnostic rate achieved 66.66%～100% in 120 liver specimens.Conclusions The diagnostic standard of histological activity index is useful as either an alternative or supplement to the conventional terminology and KnodellHAI.更多还原