【摘要】 目的　研究烟草特异性亚硝胺对地鼠颊囊粘膜的作用。方法　以烟草特异性亚硝胺及尼古丁涂抹地鼠颊粘膜 ,每周 3次 ,共 6个月。结果　颊粘膜几乎 10 0 %产生改变 ,主要为上皮增生及过角化 ,并有上皮异常增生产生。结论　烟草特异性亚硝胺对地鼠颊粘膜有较大危害 ,可引起粘膜癌前病变。更多还原

【Abstract】 Objective To study the effects of tobacco-specific nitrosamines (TSNA) and nicotine on hamster cheek pouch and gastric mucosa.Methods TSNA and nicotine were used either alone or in combination to paint hamster’s cheek mucosa 3 times per week for 6 months.Results Histologic changes,mainly epithelial hyperplasia and hyperkeratosis,were produced in nearly 100% of specimens.Conclusion TSNA is harmful to the hamster’s cheek pouch mucosa and is possible to induce premalignant lesions.更多还原