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蛙下丘听觉神经元对双耳强度差检测功能的建模和仿真

MODELING AND SIMULATION OF INTERAURAL-LEVEL-DIFFERENCEDETECTION OF AUDITORY NEURONS IN THE INFERIOR COLLICULUS IN FROGS

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【作者】 沈恩华章惠明顾凡及

【Author】 SHEN En-Hua, ZHANG Hui-Ming, GU Fan-ji(Center for Brain Science Research, Liren Lab, Dept. of Physiology & Biophysics, School of Life Science, Fudan Univ., Shanghai 200433, China)

【机构】 复旦大学生命科学学院生理学和生物物理学系立人实验室脑科学研究中心!上海200433

【摘要】 建立了蛙下丘听觉神经元对双耳刺激强度差检测功能的一个数学模型。按此模型所作的计算机仿真和相应实验结果比较的一致性支持了下列假设 :下丘中的EO神经元对同侧刺激不产生反应可能是由于接受了来自同侧的强烈抑制性输入 ,从而掩盖了它同时接受到的来自同侧耳的兴奋性输入。而来自同侧的抑制性输入 ,与来自对侧的兴奋性输入可能通过突触前抑制的相互作用 ,则导致了EE神经元的双耳抑制现象。

【Abstract】 A mathematical model of interaural-level-difference detection in auditory neurons in the frog inferior colliculus was established in this paper. The accordance between the simulation and experimental results supports the following hypothesis: The reason that the EO neuron does not show any response to the ipsilateral stimuli is probably that ipsilateral inhibitory input overcome the ipsilateral excitatory input. The reason that EE neuron display binaural inhibition is possibly that a presynaptic interaction occurs between inhibitory inputs from the ipsilateral side and excitatory inputs from the contraleteral side.

【基金】 国家自然科学基金资助项目!(批准号 ) :39970199
  • 【文献出处】 生物物理学报 ,ACTA BIOPHYSICA SINICA , 编辑部邮箱 ,2000年03期
  • 【分类号】Q811.3
  • 【被引频次】2
  • 【下载频次】50
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