【摘要】 目的 :探讨慢性单纯性胆囊炎并胆囊内结石对肝脏的影响。方法 :以慢性胆囊炎并胆囊内结石为观察组 (2 7例 ) ,胃十二指肠溃疡及外伤性脾破裂为对照组 (15例 )。两组术前均作各种常规及超声图像检查 ,尽可能排除该病以外因素对肝脏的影响。手术采取硬膜外麻醉 ,术中仔细探查 ,随机抽取 15例观察组胆囊胆汁行细菌培养 ,距胆囊底 7cm左右楔形切取肝组织作组织病理学检查。结果 :观察组均有间质性肝炎 ,以左叶明显 ;对照组仅 4例有轻微间质性肝炎。结论 :慢性单纯性胆囊炎并胆囊内结石可引起肝组织病理改变 ,其机理可能是基于胆汁成分异常改变及胆道动力学改变引起胆囊结石 ,在胆管炎及胆管周围炎的基础上 ,进一步损害肝脏更多还原

【Abstract】 Objective:To observe the effect of chronic calculous cholecystitis(CCC) upon the liver.Method: The patients with CCC,and with peptic ulcer or/traumatic rupture of the spleen were divided into the experimental and the control groups,respectively,both recepted routine laboratory test and ultrosonography.At Laporotomy,a piecemeal tissue of liver was resected from right lobe of the patients with CCC at 7cm far from the bed of gallbladder for pathologic study, and the bile was drawn for the culture of bacteria.Result:Mesenchymal hepatitis occurred in the liver of all the 27 cases in the experimental group,especially in left lobe,but in contrast, only 4s mild mesenchymal hepatitis occurred in patients of the control group.Conclusion:The CCC was relative to the mesenchymal hepatitis,the mechanism may be related with the abnormal change of the bile compound,then cholangitis and paracholangitis may cause the liver injury further.更多还原