【摘要】 为了探讨胶质细胞源性神经营养因子对脊髓运动神经元和感觉神经元的作用 ,本实验采用抗胶质细胞源性神经营养因子受体 -α多克隆抗体免疫组织化学方法 ,观察了胶质细胞源性神经营养因子受体 -α在成年大鼠腰段脊髓和背根节的分布。结果发现 :胶质细胞源性神经营养因子受体 -α免疫反应出现于成年大鼠腰段脊髓神经元和背根节神经元中。提示 :胶质细胞源性神经营养因子受体 -α可能对脊髓运动神经元、背根节神经元具有一定的调节作用更多还原

【Abstract】 In order to investigate the effect of glial cell line derived neurotrophic factor(GDNF)in the sensory and motor neurons of spinal cord, the present study observed the localization of GDNFR α in neurons of lumbar spinal cord and DRG of adult rat with anti GDNFR α polyclonal immunohistochemical staining technique. It was shown that the positive GDNFR α immunoreactivity was present in the motor neurons of lumbar spinal cord and sensory neurons and nerves in the DRG. These results suggested that GDNF might have some important effects on the motor neurons of spinal cord and sensory neurons in DRG. (Figures 1～4 on plate 24)更多还原