【摘要】 目的 :研究前列腺特异抗原 (PSA)与前列腺增生腺体体积的关系及其在前列腺癌 (PCa)诊断中的价值。方法 :75例前列腺增生症 (BPH )患者根据其 PSA >或≤ 4μg/ L分为两组 ,另有 2 5例 PCa患者 ,术前用放射免疫法测定血清 PSA。所有患者经 B超测出前列腺体积 ,用 t检验和相关分析研究各组间的差异及相关性。结果 :PSA >4μg/ L的 BPH较之 PSA≤ 4μg/ L者 ,腺体体积显著增大且 PSA和 PSA密度 (PSAD)显著增高。整个BPH组 PSA和前列腺体积之间存在显著相关性 ,其中 PSA>4μg/ L 者却没有这种相关性。结论 :一部分 BPH由于腺体增大和其他干扰因素使 PSA增高 ,且 PSA与前列腺体积失去相关性 ,影响了 PSA和 PSAD的诊断准确性。更多还原

【Abstract】 Purpose: To study the relationship between prostate specific antigen (PSA) and prostate volume.Methods:The srum PSA levels and prostate volume in 75 cases of benign prostatic hyperplasia (BPH) and 25 cases of prostate cancer (PCa) were detected. The BPH patients was divided into two groups depending on their PSA greater or not greater than 4 μg/L. Results: When PSA>4 μg/L, prostate volume, PSA and PSAD of BPH were all significantly higher than BPH with PSA less than or equal to 4 μg/L. There was linear correlation between PSA and prostate volume in BPH, but it lost while PSA>4 μg/L. Conclusions: Serum PSA levels rasie of some BPH raise due to larger prostate volume and other reasons and PSA lost its correlation with the volume, this influence the usage of PSA,PSAD in the differential diagnosis of BPH and PCa.更多还原