【摘要】 以白介素 - 1刺激增殖的血管平滑肌细胞为模型 ,按照直接试验设计法确定研究方案 ,探讨葛根素 (A)、淫羊藿甙 (B)、黄芩甙 (D)、陈皮甙 (E)、香蒲新甙 (F)等对增殖血管平滑肌细胞凋亡的交互作用。结果显示 :凋亡百分率与各药的浓度关系式为 :Y =12 0 7- 5 2 4× 10 -4 B +0 11G +9 60× 10 -7AD - 5 0 9× 10 -7BF - 2 2 0× 10 -4 EG(G表示时间 ;Y表示凋亡率 ) ,由此可见 ,葛根素与淫羊藿甙对增殖血管平滑肌细胞有促凋亡作用 ,且有明显协同作用。验证实验结果亦表明 :葛根素( 10 -7mol L)有促进增殖血管平滑肌细胞凋亡的作用 ,凋亡率为 17 0 %。更多还原

【Abstract】 Stimulating the vascular smooth muscle cell with IL-1 as the pattern, according to the direct test design to determine the research project, discuss the interaction of Puerarin, Icariin, Baicalin, Hesperidose, Typhaneoside on apoptosis of the proliferated vascular smooth muscle. The result showed the relationship of the rate of apoptosis to the concentrations of the herbs was as followed: Y=12.07-5.24×10 -4 B+0.11G+9.60×10 -7 AD-5.09×10 -7 BF-2.20×104EG(G as time, Y as the rate of apoptosis). From this, it could be seen that the puerarin and icariin could promote the apoptosis of the proliferated vascular smooth muscle and the synergism was obvious. The verification test also indicated the puerarin(10 -7 mol/L) could promote the apoptosis and the rate was 17.0%.更多还原