【摘要】 对小鼠以能允许的最大浓度 10 %的硒化低聚糖混悬液 0 .4 m L/ 10 g ig,测不出 LD50 ,故根据新药审批办法中对急性毒性的要求 ,进行了最大耐受量 ( MTD)的测定 ,当给予小鼠硒化低聚糖 16g· kg-12 4 h,对小鼠未见明显毒性反应 ,表明其 MTD>16g· kg-1。对小鼠 S180 肉瘤按 4 .0 ,2 .0 g· kg-1的剂量连续灌胃给药 9d,各剂量组小鼠均表现出明显的抑瘤作用 ,其中以中剂量组 ( 3.0 g· kg-1)为最佳 ,其抑瘤率达 67.77% ,与阳性对照药物替加氟片 ( FT- 2 0 7)的抑瘤率 ( 70 .37% )接近 ,低剂量组抑瘤率为 4 0 .77% ,高剂量组为 31.4 8%。更多还原

【Abstract】 In this paper,the acute toxicity and antitumour effect of selenooligosaccharides prepared by our lab were investigated,and compared with that of Ftorafur(FT207).Even if rats were given selenooligosaccharides 0.4ml/10g ig which was the maximum concentration (10%) that could be allowd,LD 50 couldnt be determined.Therefore,according to the requirements of the new drug methed of examination and approval,MTD was determined.When rats were given selenooligosaccharides 16g·kg 1 ·24h,no obriously tozic reaction arised.So,it snowed that MTD of selene oligosaccharioles was beyond 16g·kg 1 .When three groups of rats with tumour (S 180 ) continued to be poured into stomach for nine days respectively with 4.0,3.0 and 2.0g·kg 1 ,three dose groups of rats had obvious antitumor effect.However,the middle dose group(3.0g·kg 1 was best and its antitumour rate was up to 67.77%,which was close to that of the positive contrast drugftorafur (FT207),and in the meantime,the low dose group was 40.77% and the high group was 31.48%.更多还原