【摘要】 目的　观察乐舒痰对小儿急性下呼吸道感染的祛痰效果以及量化咳嗽、峰流值 (PEF)作为疗效观察指标的可行性。方法　将 10 6例急性下呼吸道感染的患儿随机分为治疗组 5 5例和对照组 5 1例 ,并设计了量化咳嗽和 PEF等观察指标。结果　两组患儿的综合疗效无明显差异 (P>0 .0 5 ) ,但乐舒痰组患儿的咳嗽、肺部干性罗音及 PEF恢复正常的时间明显短于对照组 ((P<0 .0 5 )。同时还显示 ,量化咳嗽和 PEF能更早地反映上述统计学上的差异。结论　 1乐舒痰是一种安全有效的祛痰剂 ;2量化咳嗽和 PEF是开展祛痰药物对小儿祛痰作用研究的两个客观而实用的指标。更多还原

【Abstract】 Objective To observe the clinical efficacy of Ambroxol in the treatment of children with acute lower respiratory tract infection (ALRTI) and the practicability of number of cough bouts (NCB) and peak expiratory flow (PEF) in studying the expectorant in children with ALRTI.Methods 106 children with ALRTI were divided into two groups by using the methods of open control study,of which 55 cases were treated with Ambroxol and 51 with acute bronchitis syrup.Results No significant difference in clinical efficacy between the two groups was found.However,in the Ambroxol treated group,the duration of the children′s cough,dry rale and PEF recovery was shorter than that in the control group (P<0 05).At the same time,it was found that NCB and PEF could earlier reflect the above statistical difference.Conclusion Ambroxol was the same effective as acute bronchitis syrup and NCB and PEF were two objective and reliable parameters in studying theexpectorant in children with ALRTI.更多还原