【摘要】 目的 :比较黄芩甙与甘露醇、地塞米松对感染性脑水肿的治疗作用 ,为脑水肿的临床治疗探讨新的方法。方法 :应用感染性脑水肿模型 ,将 40只SD大鼠随机分为感染性脑水肿 (BE)组、甘露醇治疗 (MAN)组、地塞米松治疗 (DXM)组、黄芩甙治疗 (BC)组及生理盐水对照 (NS)组 ,观察脑组织含水量、干脑组织钠、钾离子含量、伊文思兰 (EB)含量、脑组织病理形态学变化。结果 :大鼠脑组织含水量、EB含量、钠离子含量BE组高于其他组 (P <0 .0 1 )。MAN ,DXM ,EC三组间脑组织含水量、钠离子含量差异无显著性 (P >0 .0 5)。BC组的EB含量高于MAN ,DXM组 (P<0 .0 1 )。BE组钾离子含量低于生理盐水组和BC组 (P <0 .0 1 ) ;与MAN ,DXM组相近 (P >0 .0 5)。MAN ,DXM ,BC组脑组织水肿程度较BE组减轻 ,仅见少量的血管周围间隙增宽 ,偶有神经细胞核固缩 ,DXM组无神经细胞空泡样变性。结论 :黄芩甙与甘露醇、地塞米松对于感染性脑水肿均有类似的治疗效果 ,它们的作用强度相近似 ,但作用机制不尽相同更多还原

【Abstract】 Objective: To compare the therapeutic effects of baicalin, mannitol and dexamethasone on infective brain edema(IBE) in rats. Methods: Forty normal Sprague Dawley(SD) rats (200±30)g by weight were divided into 5 groups randomly: (1) normal saline control group(NS,n=8); (2) infective brain edema group(BE, n=8); (3) mannitol treatment group(MAN, n=8); (4) dexamethasone treatment group(DXM, n=8); and (5) baicalin treatment group(BC, n=8). Pertussis bacilli(PB, contained bacilli in 10.8·10 9,0.2?ml -1 ·kg -1 ) were injected into the left carotid arteries through the left common carotid arteries by puncture to obtain BE models. The contents of brain water, sodium ion, potassium ion and Evans blue in brain tissues were observed too. Results: The contents of brain water, sodium ion, and EB in BE group were higher than those in BE group(P<0.01), they decreased in MAN, DXM, BC groups and were lower than those in BE group(P<0.01). In MAN,DXM,BC groups, there were no significant difference in the contents of brain water and sodium ion(P>0.05). The EB content in BC group was higher than that in MAN and DXM groups(P<0.01). The content of potassium ion in BE group was higher than that in MAN and DXM groups, the content of potassium ion was similar to that in NS group, but lower than that in BC group. Light microscope inspection in MAN, DXM and BC groups showed lessened brain edema, slight increase of perivascular space, and occasional nerve cell pyknotic nucleus. We found on nerve cell vacuolar degeneration in DXM group. Conclusion: Baicalin, mannitol and dexamethasone all have similar protective effects on infective brain edema in rats. [更多还原