节点文献

8-Cl-cAMP对人恶性胶质瘤TJ899细胞c-myc基因表达的影响

Effects of 8-Cl-cAMP on the expression of c-myc gene in human malignant gliomatosis TJ899 cells

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 陈奎生尹先印殷智榕姜国忠

【Author】 Chen Kuisheng , Yin Xianyin, Yin Zhiyong,Jing Guozhong (Department of Pathology, Henan Medical University, Zhengzhou 450052)

【机构】 河南医科大学病理教研室!郑州 450052河南医科大学二附院脑外科!郑州 450003河南医科大学病理教研室!郑州 450052

【摘要】 目的:观察8-Cl-cAMP对人恶性胶质瘤TJ899XLEQ c-myc基因表达的影响。方法:体外分组培养TJ899细胞,采用原位杂交方法观察实验组和对照组TJ899细胞c-myc基因表达情况。结果:加8-Cl-cAMP的实验组较不加8-Cl-cAMP的对照组TJ899细胞c-myc基因表达降低。结论:8-Cl-cAMP可下调TJ899细胞 c-myc基因表达。

【Abstract】 Objective:To observe the effects of 8-Cl-cAMP on the expression of c-myc gene in human malignant gliomatosis TJ899 cells.Meth- ods:TJ899 cells were cultured in vitro,the expression of c-myc gene wre studied by in situ hybridization.Results:The expression of c-myc gene in the experimential group which added 8-Cl-cAMP was weaker than that in the control group which no 8-Cl-cAMP added. Conclusion:8-Cl-cAMP could suppress the gene expression of c-myc in YJ899 cells.

  • 【文献出处】 河南实用神经疾病杂志 ,Henan Journal of Practical Nervons Diseases , 编辑部邮箱 ,2000年05期
  • 【下载频次】10
节点文献中: