【摘要】 探讨 5 - Fu用药途径 ,发挥其更好疗效。方法 :选择 13例消化道恶性肿瘤患者 ,术前用 5 - Fu腹腔灌注给药 ,3h后取腹腔液、门静脉血和外周循环血样 ,用我们建立的 HPL C检测方法 ,分析血样中 5 - Fu的含量。结果 :13例肿瘤病人体液样品中 5 - Fu浓度平均水平分别为腹腔液 (12 0 2 .0 2 6± 39.44 2 ) m g/ L,门静脉血 (2 99.882± 14.0 9) mg/ L,外周血 (7.5 12± 1.0 46 ) mg/ L。腹腔液比外周血高 16 0倍 ,门静脉血比外周血高 40倍。结论 :腹腔注射 5 - Fu后可在腹腔、门静脉维持高的药物浓度 ,进入体循环的量极少 ,对预防进展期消化道恶性肿瘤术后腹腔和肝脏转移有指导意义。更多还原

【Abstract】 Objective:To probe into administration of 5 Fu so as to bring its effect to full play Method:Select 13 cases with malignant tumor of digestive tracts and apply celiacperfusion of 5 Fu to them In three hours time,sample theascites,portal vein and pheripheral circulation blood,and analyse the 5 Fu content of the sample were tested with our established HPLC method Results:The average levels of 5 Fu concentration of the body fluid from the 13 cases are respectively ascites(1 202 026±39 442)mg/L,portal vein blood (299 882±14 09)mg/L,pheripheral blood (7 512±1 046)mg/L The level in the ascites is 160 times of that in the pheripheral blood,while in theportal vein,40 times of that in the pheriphery Conclusion:With the 5 Fu injection of the abdominal cavity,the concentration maintains high in the cavity and portal vein,with little getting into the blood circulation,and thus has significance in preventing post operative metastasis of advanced malignant tumor of digestive tract to the cavity and liver更多还原